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KMID : 0357919790130040463
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Korean Journal of Pathology
1979 Volume.13 No. 4 p.463 ~ p.467
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Immune 4ntibody in Multiparous Women
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김애식(金愛植)/Ae Seek Kim
김상인(金相仁)/Sang In Kim
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Abstract
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For the diagnosis of hemolytic disease of newborn especially due to ABO group
incompatibility, presence of immune antibody in blood of mother and/or infant is
essential.
Rosner's modified 2-Mercaptoethanol reduction method is simple and sensitive. With
this method we have conducted some basic stuffy of immune antibody in multiparous
women with blood group 0 and
The results are as fellows;
1) The mean immune antibody titer of group 0 multiparous women (1:8) is significantly
higher than control group (1:2) who are group 0 girls without history of transfusion or
pregnancy.
2) Mean immune antibody titer is significantly different according to their husband blood
groups. Group 0-A couple has higher antibody titer (1:16) than group 0-B or group 0-0
couple
3) Immune antibody titer shorts no significant correlation with age, number of
pregnancy or time lapse from last delivary.
In conclusion a newborn who is born to group 0 mother and group A father is most
subject to ABO hemolytic disease of newborn than other blood group combinations.
Antenatal determination of immune antibody titer in group 0 mother could be helpful for
the diagnosis and prediction of development of ABO hemolytic disease of newborn.
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